Core Structure of gp41 from the HIV Envelope Glycoprotein
نویسندگان
چکیده
منابع مشابه
Core Structure of gp41 from the HIV Envelope Glycoprotein
The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell receptors, while gp41 mediates fusion between viral and cellular membranes. Previous studies identified an alpha-helical domain within gp41 composed of a trimer of two interacting peptides. The crystal structure of this comple...
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The x-ray crystal structure of the gp120 core derived from the HXBc2 strain of HIV-1, in a ternary complex with two-domain CD4 and a neutralizing antibody, has been solved [1]. The gp120 core contains deletions of the V1, V2 and V3 variable loops and of the Nand C-termini, compared with full-length gp120. The implications of this structure for understanding the interaction of the HIV-1 envelope...
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ژورنال
عنوان ژورنال: Cell
سال: 1997
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80205-6